Clos Saint-Jacques is a Premier Cru vineyard used to produce red wine from Pinot noir grapes in the Côte de Nuits region of Burgundy.

The vineyard was named after a statue of Saint James that had been placed in the area, as it was a resting point on the way to Santiago de Compostela, the destination of the Way of St. James pilgrimage.

The vineyard is 6.7 hectares in size and there are five strips, running from the top to the bottom of the vineyard, currently owned by five different producers.

The largest holder is Domaine Armand Rousseau with the original 2.20 hectares purchased by the Domaine. Sylvie Esmonin, the granddaughter of Henri Esmonin, holds 1.60 hectares. Bruno Clair and Maison Louis Jadot own 1 hectare each, which was split between them from the land purchased by Domaine Clair-Dau. Domaine Fourrier holds 0.89 of a hectare that was originally purchased by the family.